Opportunity Information: Apply for PAR 22 025

The NIDCD Clinical Research Center Grant (P50, Clinical Trial Optional), funding opportunity number PAR-22-025, is a National Institutes of Health (NIH) discretionary grant program focused on supporting clinical research centers that can meaningfully move the field forward in diagnosing, preventing, treating, and reducing the impact of human communication disorders. The opportunity is administered by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA (Assistance Listing) 93.173, and it uses the P50 "center grant" mechanism, which is typically intended to build and sustain a coordinated, multi-project research effort rather than a single stand-alone study.

For this program, NIDCD uses a broad definition of clinical research. Projects must involve people with communication disorders or the use of data and/or tissues obtained from individuals with a communication disorder. The scientific scope spans essentially the full range of NIDCD mission areas, including disorders of hearing, balance, smell, taste, voice, speech, and language. The announcement makes clear that many kinds of clinically oriented work can fit, such as studies addressing prevention, disease mechanisms (pathogenesis and pathophysiology), diagnosis, treatment, clinical management, and epidemiology. Importantly, proposing a clinical trial is allowed but not required, so applicants can build centers around observational studies, diagnostic validation, biomarker work, natural history studies, intervention development, or full interventional trials, as long as the overall program remains grounded in human clinical research relevant to communication disorders.

Eligibility is broad and includes a wide mix of public and private organizations. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The notice also highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it draws clear boundaries around foreign participation: non-U.S. (non-domestic) entities and non-U.S. components of U.S. organizations are not eligible to apply, though foreign components are allowed when they meet the NIH Grants Policy Statement definition (meaning a U.S. applicant can include a foreign component in the project under NIH rules, even though a foreign institution cannot be the applicant organization).

Key administrative details provided include an original closing date of 2024-10-09, and a creation date of 2021-10-07. The award ceiling and expected number of awards are not specified in the provided data, which generally means applicants need to consult the full funding announcement and NIDCD guidance (and often NIDCD program staff) for budget expectations, allowable costs, center structure requirements, and review considerations typical of P50 applications. Overall, the program is aimed at building strong, collaborative clinical research centers that can generate clinically relevant evidence and tools to improve outcomes for people with communication disorders, with flexibility to include clinical trials when they make sense for the center's goals.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCD Clinical Research Center Grant (P50 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173.
  • This funding opportunity was created on 2021-10-07.
  • Applicants must submit their applications by 2024-10-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIDCD Clinical Research Center Grant (P50, Clinical Trial Optional) - PAR-22-025

What is this funding opportunity?

This opportunity is the NIDCD Clinical Research Center Grant using the P50 center grant mechanism. It is a National Institutes of Health (NIH) discretionary grant program administered by the National Institute on Deafness and Other Communication Disorders (NIDCD). The funding opportunity number is PAR-22-025.

What is the goal of the NIDCD Clinical Research Center Grant program?

The program is intended to support clinical research centers that can meaningfully move the field forward in diagnosing, preventing, treating, and reducing the impact of human communication disorders.

Which NIH institute administers this grant?

The program is administered by the National Institute on Deafness and Other Communication Disorders (NIDCD), which is part of the National Institutes of Health (NIH).

What is the Assistance Listing (CFDA) number for this program?

The Assistance Listing (formerly CFDA) number provided for this opportunity is 93.173.

What type of grant mechanism is a P50?

P50 is a "center grant" mechanism. It is typically designed to build and sustain a coordinated, multi-project research effort rather than support a single stand-alone study.

Are clinical trials required under this opportunity?

No. Clinical trials are allowed but not required. The opportunity is described as "Clinical Trial Optional," so a center can include clinical trials when appropriate, but can also be built around other forms of clinical research.

How does NIDCD define "clinical research" for this program?

NIDCD uses a broad definition of clinical research for this program. Projects must involve people with communication disorders or the use of data and/or tissues obtained from individuals with a communication disorder.

What scientific areas are within scope for this clinical research center grant?

The scope spans the full range of NIDCD mission areas, including disorders of hearing, balance, smell, taste, voice, speech, and language.

What kinds of clinically oriented studies can fit under this program?

The announcement indicates that many types of clinically oriented work may fit, including studies addressing prevention, disease mechanisms (pathogenesis and pathophysiology), diagnosis, treatment, clinical management, and epidemiology.

Can a center application focus on observational or non-interventional clinical research?

Yes. Because clinical trials are optional, applicants may build centers around observational studies, diagnostic validation, biomarker work, natural history studies, or intervention development, as long as the overall program is grounded in human clinical research relevant to communication disorders.

What does it mean that projects must be grounded in human clinical research?

Based on the provided description, the center's projects must involve people with communication disorders or use data and/or tissues from individuals with a communication disorder, and the overall program must be relevant to improving understanding, diagnosis, prevention, treatment, or management of communication disorders.

Who is eligible to apply for this grant opportunity?

Eligibility is broad and includes many public and private organizations. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; non-federally recognized Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses.

Are any specific institution types explicitly highlighted as eligible?

Yes. The notice highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

Can foreign (non-U.S.) organizations apply as the applicant institution?

No. Non-U.S. (non-domestic) entities are not eligible to apply as the applicant organization for this opportunity.

Are non-U.S. components of U.S. organizations eligible to apply?

No. Non-U.S. components of U.S. organizations are not eligible to apply as the applicant.

Can a U.S. applicant include a foreign component in the project?

Yes. While foreign institutions cannot be the applicant organization, foreign components are allowed when they meet the NIH Grants Policy Statement definition. This means a U.S. applicant may include a foreign component under NIH rules, even though the foreign institution itself cannot submit the application as the primary applicant.

What are the key dates mentioned for this opportunity?

The provided administrative details include a creation date of 2021-10-07 and an original closing date of 2024-10-09.

Is the award ceiling provided?

No. The award ceiling is not specified in the provided information.

Is the expected number of awards provided?

No. The expected number of awards is not specified in the provided information.

What should applicants do if budget expectations and center structure requirements are not listed here?

Based on the provided description, applicants may need to consult the full funding announcement (PAR-22-025) and NIDCD guidance for budget expectations, allowable costs, center structure requirements, and review considerations typical of P50 applications, and may also consider contacting NIDCD program staff for clarification.

What is the overall program emphasis for funded centers?

The program emphasizes building strong, collaborative clinical research centers that can generate clinically relevant evidence and tools to improve outcomes for people with communication disorders, with flexibility to include clinical trials when they align with the center's goals.

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