Opportunity Information: Apply for PA 26 001
The NIH opportunity PA 26-001, titled "Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)," is designed for organizations that already hold certain active NIH research awards and need additional funds to cover increased project costs that were not anticipated at the time the original (or competing renewal) application was awarded. The key point is that this is not a new standalone research grant. It is an administrative supplement, meaning extra funding added onto an existing parent award to keep the originally approved work on track when unexpected cost increases arise.
These supplement requests must stay strictly within the scope of the peer-reviewed and approved parent project. In practical terms, the supplement cannot be used to launch a new research direction, add aims that substantially change the science, or expand the project beyond what NIH originally reviewed and approved. The supplement is meant to address unplanned needs that still fit the existing project, such as legitimate cost increases, unforeseen resource needs, or other budget impacts that emerged after the award was made, as long as the proposed activities remain consistent with the approved aims and approach.
Eligibility is tied to the status of the parent award. The parent grant or cooperative agreement must be active and cannot be in a no-cost extension period. In addition, the work supported by the supplement has to be completed within the current competitive segment of the parent award. That timing requirement matters because administrative supplements are intended to help complete the approved project during its funded project period, not to extend it beyond the competitive segment or shift it into a different funding timeline.
NIH treats these applications as prior approval requests under the NIH Grants Policy Statement (referenced as Section 8.1.2.11). Instead of going through a standard competitive peer review like many new applications, the request is routed directly to the Grants Management Officer for the parent award. Even so, funding is not guaranteed. Availability depends on whether the awarding NIH Institute or Center (IC) has funds and chooses to support a supplement for that specific award. Because of that uncertainty, NIH emphasizes that applicants should discuss the potential request before submitting, coordinating with both the grants management and program officials at the awarding IC or Office (ICO). That pre-submission conversation is effectively part of the process, since it helps confirm whether the request fits policy, fits scope, and is realistically fundable.
The opportunity is broadly available across many applicant types commonly eligible for NIH funding. This includes state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those nonprofit categories); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The notice also highlights additional eligible applicant types such as Indian/Native American tribal governments that are not federally recognized, eligible federal agencies, U.S. territories or possessions, faith-based or community-based organizations, regional organizations, and non-U.S. entities (foreign organizations), though any foreign involvement must comply with current NIH policy constraints.
A major compliance issue in this NOFO is NIH's updated policy on international collaborations that involve money flowing to foreign institutions. NIH states that it will no longer issue awards (including new awards, renewals, or non-competing continuations) to domestic or foreign entities if the project includes foreign subawards or subcontracts, unless the application is submitted under a NOFO specifically designated for funded international collaborations. This requirement took effect May 1, 2025. For this particular administrative supplement NOFO, applications that include foreign subawards or subcontracts are considered noncompliant and will not be considered for funding. At the same time, NIH clarifies that the policy does not prohibit all foreign-related activity. Unfunded international collaborations, allowable foreign components that do not involve a foreign subaward/subcontract arrangement, payments to foreign consultants, and purchasing unique equipment or supplies from foreign vendors may still be possible, provided they align with the parent award and comply with NIH policy.
From a basic administrative standpoint, the opportunity is issued by the National Institutes of Health, categorized as discretionary funding, with the funding instrument listed as a grant and the activity area as health (CFDA 93.310). The original closing date shown is November 30, 2028. The notice does not specify an award ceiling or expected number of awards in the provided data, reinforcing the idea that these supplements are handled case-by-case depending on IC priorities and available funds rather than as a fixed, large cohort competition.
Overall, the purpose of PA 26-001 is to give current NIH awardees a pathway to request additional funds when real, unforeseen cost increases threaten the ability to carry out the already-approved research plan during the active competitive segment. The strongest applications under this NOFO are typically those that clearly explain what changed, why the added costs could not have been anticipated at the time of award, how the request remains within scope, and why the supplement is necessary to complete the approved project as originally intended, while also meeting NIH's updated restrictions on foreign subawards and subcontracts.Apply for PA 26 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2025-11-26.
- Applicants must submit their applications by 2028-11-30.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PA 26-001 Administrative Supplements (Parent Admin Supp Clinical Trial Optional)
What is NIH PA 26-001?
PA 26-001 is an NIH funding opportunity for administrative supplements to certain existing NIH grants and cooperative agreements. It is intended for organizations that already have an active NIH research award and need additional funds to cover increased project costs that were not anticipated when the original (or competing renewal) award was made.
Is this a new standalone research grant?
No. This opportunity is not a new, standalone research grant. It is an administrative supplement, meaning added funds to an already-active parent award to help keep the originally approved work on track when unexpected cost increases arise.
What is the main purpose of an administrative supplement under this opportunity?
The purpose is to address unplanned needs or cost increases that emerged after the parent award was issued, as long as the requested supplement activities remain consistent with the approved aims and approach of the parent project and are necessary to complete the approved work during the funded competitive segment.
Do supplement activities have to stay within the scope of the parent award?
Yes. Supplement requests must stay strictly within the scope of the peer-reviewed and approved parent project. The supplement cannot be used to launch a new research direction, add aims that substantially change the science, or expand the project beyond what NIH originally reviewed and approved.
Can this supplement be used to add new aims or substantially change the science?
No. The supplement is not intended for adding new aims that would materially change the project or create a new line of research. It is intended to address unanticipated costs while keeping the originally approved project on track.
What kinds of situations might justify requesting this supplement?
Based on the information provided, justified situations include legitimate cost increases, unforeseen resource needs, or other budget impacts that arose after the award and were not anticipated at the time of the original (or competing renewal) award, as long as the proposed supplement-supported work remains consistent with the parent award's approved aims and approach.
What are the eligibility requirements for the parent award?
The parent grant or cooperative agreement must be active and cannot be in a no-cost extension period. In addition, the work supported by the supplement must be completed within the current competitive segment of the parent award.
Can an award in a no-cost extension period apply for this supplement?
No. The parent award cannot be in a no-cost extension period to be eligible for this administrative supplement under PA 26-001.
Does the supplement work have to be completed within a specific timeframe?
Yes. The work supported by the supplement must be completed within the current competitive segment of the parent award. The supplement is intended to help complete approved work during the funded project period, not to extend the project beyond the competitive segment.
How does NIH treat these supplement requests administratively?
NIH treats these applications as prior approval requests under the NIH Grants Policy Statement (referenced as Section 8.1.2.11). Rather than going through a standard competitive peer review like many new applications, the request is routed directly to the Grants Management Officer for the parent award.
Does this opportunity involve standard competitive peer review?
Not in the same way as many new NIH applications. Based on the description provided, these supplement requests are handled as prior approval requests and routed to the Grants Management Officer for the parent award, rather than proceeding through standard competitive peer review.
Is funding guaranteed if an organization submits a supplement request?
No. Funding is not guaranteed. Availability depends on whether the awarding NIH Institute or Center (IC) has funds and chooses to support a supplement for that specific award.
Should applicants talk to NIH before submitting a supplement request?
Yes. NIH emphasizes that applicants should discuss the potential request before submitting, coordinating with both grants management and program officials at the awarding Institute/Center or Office (ICO). This helps confirm that the request fits policy, stays within scope, and is realistically fundable given IC priorities and available funds.
Who can apply for PA 26-001?
This opportunity is broadly available across many applicant types commonly eligible for NIH funding, provided they already hold an eligible active parent NIH award. The listed eligible applicants include various government entities, higher education institutions (public and private), nonprofit organizations, for-profit organizations (including small businesses), and other eligible entities highlighted in the notice.
What types of government entities are eligible to apply?
Eligible government entity types listed include state, county, city, township, and special district governments, as well as independent school districts.
Are colleges and universities eligible?
Yes. Public and state-controlled institutions of higher education, as well as private institutions of higher education, are listed as eligible applicant types.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are listed as eligible, including 501(c)(3) and non-501(c)(3) nonprofits (excluding higher education institutions within those nonprofit categories, as described in the provided information).
Are for-profit organizations and small businesses eligible?
Yes. For-profit organizations (other than small businesses) and small businesses are listed among eligible applicant types, assuming they hold an eligible active NIH parent award.
Are foreign organizations eligible to apply?
Non-U.S. entities (foreign organizations) are highlighted among eligible applicant types in the provided information, though any foreign involvement must comply with current NIH policy constraints. A key constraint described is the restriction on foreign subawards or subcontracts under this NOFO.
What is the NIH policy change related to foreign subawards or subcontracts?
NIH states it will no longer issue awards (including new awards, renewals, or non-competing continuations) to domestic or foreign entities if the project includes foreign subawards or subcontracts, unless the application is submitted under a NOFO specifically designated for funded international collaborations. This requirement took effect May 1, 2025.
Are foreign subawards or foreign subcontracts allowed in applications under PA 26-001?
No. For this administrative supplement NOFO, applications that include foreign subawards or subcontracts are considered noncompliant and will not be considered for funding.
Does the restriction mean all foreign-related activity is prohibited?
No. The provided information states the policy does not prohibit all foreign-related activity. Unfunded international collaborations, allowable foreign components that do not involve a foreign subaward/subcontract arrangement, payments to foreign consultants, and purchasing unique equipment or supplies from foreign vendors may still be possible if they align with the parent award and comply with NIH policy.
Can applicants pay foreign consultants under this opportunity?
Yes, according to the information provided, payments to foreign consultants may still be possible, as long as the arrangement complies with NIH policy and remains aligned with the parent award and within scope.
Can a project purchase equipment or supplies from foreign vendors using supplement funds?
Potentially yes. The information provided indicates that purchasing unique equipment or supplies from foreign vendors may still be possible, provided it aligns with the parent award and complies with NIH policy.
What is the sponsor and general funding category for PA 26-001?
The sponsor is the National Institutes of Health (NIH). The opportunity is categorized as discretionary funding, with the funding instrument listed as a grant and the activity area as health.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.310.
What is the closing date shown for this opportunity?
The original closing date shown is November 30, 2028.
Does the notice specify an award ceiling or expected number of awards?
No. The provided information states that the notice does not specify an award ceiling or an expected number of awards, reinforcing that supplements are handled case-by-case depending on Institute/Center priorities and available funds.
What makes a supplement request stronger under PA 26-001, based on the description provided?
Strong requests typically (1) clearly explain what changed, (2) explain why the added costs could not have been anticipated at the time of award, (3) show how the request remains within scope of the approved parent project, and (4) explain why the supplement is necessary to complete the approved project as originally intended, while also meeting NIH restrictions on foreign subawards and subcontracts.
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