Opportunity Information: Apply for RFA CA 24 019

The Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) funding opportunity (RFA-CA-24-019) is a National Institutes of Health, National Cancer Institute announcement under the Informatics Technology for Cancer Research (ITCR) Program. It uses a Cooperative Agreement (U24) mechanism, which means awardees should expect substantial involvement from NIH/NCI program staff compared to a typical grant, with an emphasis on working collaboratively to meet program goals and ensure the supported resource continues to serve the broader cancer research community effectively.

The main purpose of the FOA is to support the continued development, maintenance, and long-term sustainment of high-value informatics research resources that are already in use and have demonstrated broad adoption and impact. These resources can include software tools, data platforms, knowledgebases, workflows, standards, or other informatics infrastructure that improves how cancer-related data are acquired, managed, analyzed, visualized, and interpreted. The scope covers the full cancer research continuum, including cancer biology, diagnosis and treatment, early detection, risk assessment and prevention, cancer control and epidemiology, and research focused on cancer health disparities. In practical terms, the FOA is aimed at keeping important, community-relevant informatics tools reliable, accessible, and continuously improving so that researchers can depend on them for ongoing scientific work.

A key point is that this announcement is not meant for creating brand-new tools from scratch or for early or advanced-stage development efforts that primarily focus on building new capabilities. Instead, it is specifically designed for projects that have already produced a widely adopted tool or resource and now need support to sustain operations and strengthen the resource over time. The FOA places special emphasis on improving the user experience and overall availability of the resource, which can include things like better documentation, easier installation or access, improved interfaces, scalability, performance, reliability, interoperability, user support, training materials, and responsiveness to user needs.

To be competitive, applicants are expected to present a clear sustainment plan that justifies why the resource should continue to be supported and how it has already benefited the cancer research field. That plan should also explain how the resource will continue to generate value in the future, including how it will stay current as research practices, data types, and community expectations evolve. The FOA also expects applicants to describe concrete methods for assessing and maximizing value to researchers, which typically means having meaningful usage metrics, feedback loops, evaluation frameworks, and a roadmap driven by community priorities rather than by the preferences of the development team alone. Another major theme is deep engagement with the target user community, including mechanisms to support collaboration, encourage contributions, and ensure the resource remains aligned with real-world research workflows and emerging needs.

Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other eligible entities. The FOA also explicitly highlights eligibility for a range of organizations such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) entities.

Administratively, the opportunity is categorized as discretionary funding and falls under education and health activity areas. It lists CFDA numbers 93.393, 93.394, 93.395, 93.396, and 93.399. The posting shows an original closing date of 2024-11-15 and a creation date of 2023-12-14. The clinical trial designation is "optional," which typically indicates that proposing a clinical trial is not required to be responsive, but applicants should follow NIH rules carefully if any proposed activities meet the NIH definition of a clinical trial.

Overall, this FOA is best understood as NCI's mechanism for keeping proven cancer informatics resources healthy and useful: funding operational continuity, improving usability and access, strengthening community engagement, and ensuring that widely used tools do not stagnate or disappear at the point when researchers most depend on them.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
  • This funding opportunity was created on 2023-12-14.
  • Applicants must submit their applications by 2024-11-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA CA 24 019

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