Opportunity Information: Apply for PA 15 354
The SBIR Technology Transfer (R43/R44) opportunity, Funding Opportunity Announcement PA 15-354, is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant program designed specifically to move inventions and know-how developed inside NIH intramural laboratories into the private sector for further development and commercialization. In practical terms, the program is meant to bridge the gap between promising NIH-owned technologies and the market by providing SBIR funding to a qualified U.S. small business that is willing to take on the work of turning an NIH-originated invention into a product or service that benefits public health.
This FOA supports SBIR projects under the R43 and R44 mechanisms, which correspond to the traditional SBIR structure of early-stage feasibility work and later-stage development. While the announcement summary does not list an award ceiling or expected number of awards, it clearly frames the purpose: fund small business research and development efforts that are explicitly tied to transferring NIH intramural technologies out of government labs and into commercial pathways. The activity areas align with NIH mission space in education and health, and the opportunity is associated with multiple CFDA program numbers (including 93.121, 93.273, 93.279, 93.350, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.853, and 93.867), reflecting the broad range of NIH Institutes and Centers that may be relevant depending on the technology and disease or application area.
A defining feature of this program is the licensing arrangement tied to NIH-held intellectual property. If a small business is selected for SBIR funding under this FOA, the company will be granted a royalty-free, non-exclusive patent license agreement for internal research use, limited to the term of the SBIR award and constrained to the field of use of the SBIR project. The intent is to give the awardee the ability to use the NIH technology to perform the SBIR-funded R&D without having to negotiate a separate paid license just to do the funded work, while still focusing the rights on the specific development scope of the award. The broader expectation is that the small business will then advance the invention toward a commercial product for public benefit, using SBIR support to reduce technical risk and increase readiness for private investment, partnerships, regulatory steps, manufacturing scale-up, or other commercialization milestones.
Eligibility is centered on U.S. small business concerns, consistent with SBIR requirements. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply. However, the FOA notes that foreign components (as defined in the NIH Grants Policy Statement) may be allowed in some circumstances, which typically means that a U.S. applicant might justify a discrete portion of work being performed outside the U.S. when it is necessary and cannot be performed domestically, subject to NIH policy and approval. The awarding agency is NIH, the funding instrument is a grant, and the opportunity was created on 2015-09-21 with an original closing date listed as 2018-01-11.
Overall, this announcement is best understood as a commercialization-focused SBIR pathway specifically aimed at NIH intramural technology transfer: NIH provides funding plus limited, royalty-free, non-exclusive internal-use patent rights during the award so that a small business can de-risk and develop an NIH-owned invention into something that can ultimately be deployed in the real world to improve health outcomes.Apply for PA 15 354
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "SBIR Technology Transfer (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.273, 93.279, 93.350, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.853, 93.867.
- This funding opportunity was created on 2015-09-21.
- Applicants must submit their applications by 2018-01-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Advancing Research on Molecular Targets and Mechanisms that Influence the Interplay Between Sex Hormones, HIV, and Addictive Substances (R01 Clinical Trials Not Allowed) Apply for RFA DA 26 007 Funding Number: RFA DA 26 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| The Confluence of Cancer Stigma and HIV Stigma in HIV-positive Individuals Diagnosed with Cancer (R01 Clinical Trial Optional) Apply for RFA CA 25 011 Funding Number: RFA CA 25 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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