Opportunity Information: Apply for RFA HD 21 002
The Centers to Advance Research in Endometriosis (CARE) (P01 Clinical Trial Not Allowed) funding opportunity (RFA-HD-21-002) is a National Institutes of Health (NIH) grant solicitation designed to build coordinated, multidisciplinary research centers focused on endometriosis. The central aim is to speed up scientific progress by bringing investigators together under a single collaborative structure that shares expertise, data, tools, and other resources. By supporting integrated programs that span basic, translational, and clinical research (while explicitly excluding clinical trials), the initiative is intended to generate stronger, faster-moving discoveries that can ultimately improve female reproductive health through better prevention strategies and more effective treatments for endometriosis.
This opportunity uses the NIH P01 center-style grant mechanism and is categorized as a discretionary grant. The program emphasizes collaboration as a core feature: applicants are expected to form a center-like entity that can pursue multiple connected lines of investigation rather than isolated projects. The research supported can include foundational biology of endometriosis, translational work that moves findings toward diagnostics or interventions, and clinical studies that do not meet the definition of a clinical trial. The overall expectation is that organizing research into a shared, multidisciplinary center will reduce duplication, encourage standardization where helpful (for example, common protocols or shared core resources), and make it easier for teams to combine complementary methods and perspectives.
The eligible applicant pool is broad and includes many types of U.S.-based organizations and governmental units. Eligible applicants listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education when applying under those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
Foreign participation is limited in a way that is typical for many NIH funding announcements. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible to apply. At the same time, foreign components, as defined in the NIH Grants Policy Statement, are allowed. In practice, this means a U.S.-based applicant can include certain foreign collaborators or activities as a foreign component when justified and structured according to NIH policy, but the primary applicant organization must be domestic and the application cannot be submitted by a foreign institution.
Key administrative details provided in the source information include an original closing date of November 30, 2020, and an award ceiling of $1,000,000. The announcement is associated with CFDA numbers 93.113, 93.313, 93.393, and 93.865, and it is listed under broad funding activity categories that include health (and also education, environment, income security, and social services within the general classification system used in the listing). Although the expected number of awards is not specified in the provided text, the structure and intent of the FOA make clear that NIH sought to stand up a set of dedicated endometriosis research centers capable of generating coordinated advances rather than single-project outcomes.
In plain terms, CARE is about creating research hubs for endometriosis: teams that deliberately integrate multiple scientific angles, share resources, and work in a coordinated way to produce insights and tools that can meaningfully improve prevention and treatment, while staying within a non-clinical-trial scope for human research.Apply for RFA HD 21 002
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Centers to Advance Research in Endometriosis (CARE) (P01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.313, 93.393, 93.865.
- This funding opportunity was created on 2020-08-31.
- Applicants must submit their applications by 2020-11-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the CARE funding opportunity (RFA-HD-21-002)?
The Centers to Advance Research in Endometriosis (CARE) (P01 Clinical Trial Not Allowed) funding opportunity, RFA-HD-21-002, is an NIH solicitation to establish coordinated, multidisciplinary research centers focused on endometriosis. The goal is to accelerate scientific progress by organizing investigators into a collaborative center structure that shares expertise, data, tools, and resources.
What is the main purpose of the CARE initiative?
The central aim is to speed up discoveries in endometriosis research by supporting integrated programs that bring together basic, translational, and clinical research approaches (without conducting clinical trials). The intent is that stronger coordination and shared infrastructure will produce faster-moving, higher-impact results that can ultimately improve female reproductive health through better prevention strategies and more effective treatments for endometriosis.
What grant mechanism does CARE use?
CARE uses the NIH P01 center-style grant mechanism. This mechanism is designed for coordinated, multi-project efforts organized under a single, collaborative structure rather than isolated, unrelated projects.
Are clinical trials allowed under this opportunity?
No. The opportunity is labeled "Clinical Trial Not Allowed," meaning the supported research can include clinical studies that do not meet the NIH definition of a clinical trial, but it cannot include clinical trials.
What types of research does CARE support?
CARE supports a program spanning basic, translational, and clinical research (excluding clinical trials). Examples described in the opportunity include foundational biology of endometriosis, translational work moving findings toward diagnostics or interventions, and clinical research activities that do not qualify as clinical trials.
What does NIH mean by a "center" approach in this program?
Applicants are expected to form a center-like entity that coordinates multiple connected lines of investigation. The emphasis is on collaboration and integration, including shared expertise, shared data and tools, and common resources that help reduce duplication and strengthen the overall research program.
Why does the FOA emphasize collaboration and shared resources?
The FOA is designed around the idea that coordinated research hubs can reduce duplication, encourage useful standardization (such as common protocols or shared core resources), and make it easier to combine complementary methods and perspectives across disciplines. This structure is intended to generate stronger and faster progress than disconnected projects working independently.
Who is eligible to apply?
The eligible applicant pool is broad and includes many U.S.-based organizations and governmental units. Examples explicitly listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (when not applying as an institution of higher education under those nonprofit categories); for-profit organizations other than small businesses; and small businesses.
Are minority-serving institutions and community-based organizations eligible?
Yes. The FOA highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; and regional organizations.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are included among the eligible applicant categories highlighted in the opportunity.
Can a foreign (non-U.S.) institution apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible to apply as the applicant.
Is any foreign participation allowed at all?
Yes. While a foreign institution cannot be the applicant organization, foreign components (as defined in the NIH Grants Policy Statement) are allowed. In practice, this means a U.S.-based applicant may include certain foreign collaborators or activities as a foreign component when justified and structured according to NIH policy.
What is the award ceiling mentioned for this opportunity?
The provided information lists an award ceiling of $1,000,000.
What was the original closing date?
The original closing date provided is November 30, 2020.
How is this opportunity categorized within NIH funding?
It is described as a discretionary grant and uses the P01 center-style structure to support coordinated endometriosis research centers.
What CFDA numbers are associated with this announcement?
The announcement is associated with CFDA numbers 93.113, 93.313, 93.393, and 93.865.
What funding activity categories are associated with the listing?
The listing is associated with broad funding activity categories that include health. It is also listed under education, environment, income security, and social services within the general classification system used in the listing.
Does the provided information specify how many awards NIH expected to make?
No. The expected number of awards is not specified in the information provided.
What kind of outcomes is CARE intended to promote?
CARE is intended to produce stronger, faster-moving discoveries by coordinating multidisciplinary teams and shared resources. The program is framed around generating insights and tools that can meaningfully improve prevention and treatment for endometriosis, while remaining within a non-clinical-trial scope for human research.
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